Great article on Forbes.com today about how a high-fat, high-simple carb diet can damage your brain and screw up the signals in the hypothalamus, the part of the brain that regulates metabolism.
Switching to a healthy diet can heal the hypothalamic damage that’s playing havic with your hunger and satiety cues.
She also points to a study by the University of Liverpool that showed that omega-3 fatty acids can mitigate some of the negative effects of the sat fats and simple carbs.
Anyway, go read the article. If you're a nutrition geek, it's fascinating.